Cell surface dynamics and cellular distribution of endogenous FcRn
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چکیده
منابع مشابه
Cell surface dynamics and cellular distribution of endogenous FcRn
A major role for FcRn is the salvage of pinocytosed IgG and albumin from a degradative fate in lysosomes. FcRn achieves this by binding IgG in a pH-dependent manner in acidic endosomes and recycling it to the plasma membrane to be released at neutral pH. This is important in maintaining high serum IgG and albumin levels and has the potential to be exploited to modulate the pharmacokinetics of a...
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A monoclonal antibody (mAb) designated 5D7 that is directed against endogenous, galactoside-specific lectin and binds to the surface of various tumor cells was used to examine the involvement of cell surface lectin molecules in cellular interactions in vitro and in vivo. The mAb 5D7 was found to inhibit asialofetuin-induced homotypic aggregation of B16 mel anoma and UV-2237 fibrosarcoma cell va...
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A monoclonal antibody (mAb) designated 5D7 that is directed against endogenous, galactoside-specific lectin and binds to the surface of various tumor cells was used to examine the involvement of cell surface lectin molecules in cellular interactions in vitro and in vivo. The mAb 5D7 was found to inhibit asialofetuin-induced homotypic aggregation of B16 melanoma and UV-2237 fibrosarcoma cell var...
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Humans suffer transient or persistent starvation due to a lack of food intake, either because of fasting, voluntary dieting, or due to the scarcity of available food. At the cellular level it is possible to possess pathological starvation during ischemia and solid tumors. Blood provides many nutrients to our cells, and researchers provide these nutrients to cells in culture in the form of en...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2017
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0182695